Deep learning classifiers provide the most accurate means of automatically diagnosing diabetic retinopathy (DR) based on optical coherence tomography (OCT) and its angiography (OCTA). The power of these models is attributable in part to the inclusion of hidden layers that provide the complexity required to achieve a desired task. However, hidden layers also render algorithm outputs difficult to interpret. Here we introduce a novel biomarker activation map (BAM) framework based on generative adversarial learning that allows clinicians to verify and understand classifiers decision-making. A data set including 456 macular scans were graded as non-referable or referable DR based on current clinical standards. A DR classifier that was used to evaluate our BAM was first trained based on this data set. The BAM generation framework was designed by combing two U-shaped generators to provide meaningful interpretability to this classifier. The main generator was trained to take referable scans as input and produce an output that would be classified by the classifier as non-referable. The BAM is then constructed as the difference image between the output and input of the main generator. To ensure that the BAM only highlights classifier-utilized biomarkers an assistant generator was trained to do the opposite, producing scans that would be classified as referable by the classifier from non-referable scans. The generated BAMs highlighted known pathologic features including nonperfusion area and retinal fluid. A fully interpretable classifier based on these highlights could help clinicians better utilize and verify automated DR diagnosis.

Neural networks have revolutionized the area of artificial intelligence and introduced transformative applications to almost every scientific field and industry. However, this success comes at a great price; the energy requirements for training advanced models are unsustainable. One promising way to address this pressing issue is by developing low-energy neuromorphic hardware that directly supports the algorithm's requirements. The intrinsic non-volatility, non-linearity, and memory of spintronic devices make them appealing candidates for neuromorphic devices. Here we focus on the reservoir computing paradigm, a recurrent network with a simple training algorithm suitable for computation with spintronic devices since they can provide the properties of non-linearity and memory. We review technologies and methods for developing neuromorphic spintronic devices and conclude with critical open issues to address before such devices become widely used.

In off-policy reinforcement learning, a behaviour policy performs exploratory interactions with the environment to obtain state-action-reward samples which are then used to learn a target policy that optimises the expected return. This leads to a problem of off-policy evaluation, where one needs to evaluate the target policy from samples collected by the often unrelated behaviour policy. Importance sampling is a traditional statistical technique that is often applied to off-policy evaluation. While importance sampling estimators are unbiased, their variance increases exponentially with the horizon of the decision process due to computing the importance weight as a product of action probability ratios, yielding estimates with low accuracy for domains involving long-term planning. This paper proposes state-based importance sampling (SIS), which drops the action probability ratios of sub-trajectories with "neglible states" -- roughly speaking, those for which the chosen actions have no impact on the return estimate -- from the computation of the importance weight. Theoretical results show that this results in a reduction of the exponent in the variance upper bound as well as improving the mean squared error. An automated search algorithm based on covariance testing is proposed to identify a negligible state set which has minimal MSE when performing state-based importance sampling. Experiments are conducted on a lift domain, which include "lift states" where the action has no impact on the following state and reward. The results demonstrate that using the search algorithm, SIS yields reduced variance and improved accuracy compared to traditional importance sampling, per-decision importance sampling, and incremental importance sampling.

Purpose: This study aims to explore training strategies to improve convolutional neural network-based image-to-image registration for abdominal imaging. Methods: Different training strategies, loss functions, and transfer learning schemes were considered. Furthermore, an augmentation layer which generates artificial training image pairs on-the-fly was proposed, in addition to a loss layer that enables dynamic loss weighting. Results: Guiding registration using segmentations in the training step proved beneficial for deep-learning-based image registration. Finetuning the pretrained model from the brain MRI dataset to the abdominal CT dataset further improved performance on the latter application, removing the need for a large dataset to yield satisfactory performance. Dynamic loss weighting also marginally improved performance, all without impacting inference runtime. Conclusion: Using simple concepts, we improved the performance of a commonly used deep image registration architecture, VoxelMorph. In future work, our framework, DDMR, should be validated on different datasets to further assess its value.

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

We formulate grasp learning as a neural field and present Neural Grasp Distance Fields (NGDF). Here, the input is a 6D pose of a robot end effector and output is a distance to a continuous manifold of valid grasps for an object. In contrast to current approaches that predict a set of discrete candidate grasps, the distance-based NGDF representation is easily interpreted as a cost, and minimizing this cost produces a successful grasp pose. This grasp distance cost can be incorporated directly into a trajectory optimizer for joint optimization with other costs such as trajectory smoothness and collision avoidance. During optimization, as the various costs are balanced and minimized, the grasp target is allowed to smoothly vary, as the learned grasp field is continuous. In simulation benchmarks with a Franka arm, we find that joint grasping and planning with NGDF outperforms baselines by 63% execution success while generalizing to unseen query poses and unseen object shapes. Project page: https://sites.google.com/view/neural-grasp-distance-fields.

机器学习潜力是分子模拟的重要工具，但是由于缺乏高质量数据集来训练它们的发展，它们的开发阻碍了它们。我们描述了Spice数据集，这是一种新的量子化学数据集，用于训练与模拟与蛋白质相互作用的药物样的小分子相关的潜在。它包含超过110万个小分子，二聚体，二肽和溶剂化氨基酸的构象。它包括15个元素，带电和未充电的分子以及广泛的共价和非共价相互作用。它提供了在{\ omega} b97m-d3（bj）/def2-tzVPPD理论水平以及其他有用的数量（例如多极矩和键阶）上计算出的力和能量。我们在其上训练一组机器学习潜力，并证明它们可以在化学空间的广泛区域中实现化学精度。它可以作为创建可转移的，准备使用潜在功能用于分子模拟的宝贵资源。

增强现实（AR）游戏是一个丰富的环境，用于研究和测试提供微妙的用户指导和培训的计算系统。在特定的计算机系统中，旨在增强用户状况意识的计算机系统受益于AR耳机中可用的传感器和计算功率。在这篇正在进行的论文中，我们提出了一个新的环境，以研究情况意识和注意力指导（SAAG）：棋盘游戏Carcassonne的增强现实版本。我们还介绍了生产SAAG管道的最初工作，包括创建游戏状态编码，游戏玩法AI的开发和培训以及情况建模和凝视跟踪系统的设计。

文化领域代表了一个有用的概念，该概念在社会科学领域进行了交叉侵占。了解人类如何在社会中组织和联系他们的思想和行为有助于了解他们对不同问题的行为和态度。但是，塑造文化领域的共同特征的选择是任意的。所需的方法是一种可以利用大量在线数据（尤其是通过社交媒体）来识别没有临时假设，偏见或偏见的文化区域的方法。在这项工作中，我们通过引入一种基于微博帖子对大型数据集的自动分析来推断文化区域的方法来朝着这个方向迈出关键一步。我们的方法是基于以下原则：从人们之间讨论的主题可以推断出文化隶属关系。具体来说，我们衡量了美国社交媒体产生的书面话语中的区域差异。从地理标记的推文中内容词的频率分布，我们找到了“用法”区域热点，从那里我们得出了区域变化的主要成分。通过在这个较低维空间中数据的层次聚类，我们的方法得出了清晰的文化领域和定义它们的讨论主题。我们获得了一个明显的南北分离，主要受非裔美国人文化的影响，并进一步连续（东西方）和不连续的（城市农村）分裂，这些师为当今美国的文化领域提供了全面的了解。

骨肉瘤是最常见的原发性骨癌，其标准治疗包括术前化疗，然后切除。化学疗法反应用于预测患者的预后和进一步治疗。坏死在切除标本上的组织学幻灯片通常评估了坏死比定义为坏死肿瘤与总体肿瘤之比。已知坏死比> = 90％的患者的预后更好。多个载玻片对坏死比的手动微观综述是半定量性的，并且可能具有观察者间和观察者间的变异性。我们提出了一种基于目标和可再现的深度学习方法，以估计坏死比，并从扫描的苏木精和曙红全幻灯片图像预测结果。我们以3134个WSI的速度收集了103例骨肉瘤病例，以训练我们的深度学习模型，验证坏死比评估并评估结果预测。我们训练了深层多磁化网络，以分割多个组织亚型，包括生存的肿瘤和像素级中的坏死肿瘤，并计算来自多个WSI的病例级坏死比。我们显示了通过分割模型估算的坏死比，高度与由专家手动评估的病理报告中的坏死比高度相关，其中IV级的平均绝对差异（100％），III（> = 90％）和II（> = 50％和<50％和< 90％）坏死反应分别为4.4％，4.5％和17.8％。我们成功地对患者进行了分层，以预测P = 10^-6的总生存率，而P = 0.012的无进展生存率。我们没有可变性的可重现方法使我们能够调整截止阈值，特别是用于模型和数据集的截止阈值，为OS的80％，PFS为60％。我们的研究表明，深度学习可以支持病理学家作为一种客观的工具，可以分析组织学中骨肉瘤，以评估治疗反应并预测患者结果。